Product search:

Mobile:+86-189 1310 9969

Tel:+86-512-62729923

Fax:+86-512-62729923

Contacts: Miss.Jia;Miss.Hu

Post Code:215000

Address:Room C316, 150 RenAi Road, Suzhou, P. R. China

The current position>>Return to home page

Chinese Name

中文名


雷尼酸锶

English Name

英文名


3,4,4a,10b-tetrahydro-2,2-dimethyl-2H-Naphtho[1,2-b]pyran-5,6-dione

Alias

别名




CAS NO.


132820-30-5

Formula

分子式


 C15H14O3

M.W.

分子量


242.27

Class

分类


贝博ballapp



β-拉帕醌(β-lapachone}化学名为3,4-二氢-2,2-二甲基-2H-萘并[1,2-b]-吡喃-5,6-二酮,属于1,2-萘醌类,最初是从产自中南美洲的天然产物 Tabe-buia avellanedae中分离得到的[1]。广泛的生物活性,包括抗细菌、抗真菌、杀锥虫、抗银屑病、消炎和抗肿瘤等[2] 。究结果表明,它对多种肿瘤细胞均显示出很好的抑制活性[3-4] ,且量时可以作为肿瘤细胞的放射增敏剂使用[5]。β-拉帕醌作为一种细胞凋亡激动剂已进人n期临床研究。
 






1、DIAZ F;MEDINA JD Furanonaphthoquinones from Tabebuia oehracea ssp.neochrysanta  1996(04) doi:10.1021/np9602022
2、PARDEE AB;LI YZ;LI CJ Cancer therapy with β-Lapachone  2002(03) doi:10.2174/1568009023333854
3、PLANCHON SM;WUERZBERGER S;FRYDMAN B β-lapachone-mediated apoptosis in human promyeloeytic leukemia (HL-60)and human prostate cancer ceils:a p53-independent Response  1995(17)
4、LI CJ;WANG C;PARDEE AB Induction of apoptosis by β-lapachone in human prostate cancer cells  1995(17)
5、BOOTHMAN DA;GREER S;PARDEE AB Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by β-lapachone(3,4-dihydro-2,2-dimethyl-2H-naphthol-[1,2-b]pyran-5,6-dione)a Novel DNA Repair Inhibitor 1987(20)
6、SCHAFFNER-SABBA K;SCHMIDT.RUPPIN KH;WEHRLI W β-lapachone:synthesis of derivatives and activities in tumor models  1984(08) doi:10.1021/jm00374a010
7、SUN JS;GEISER AH;FRYDMAN B A preparative synthesis of lapachol and related naphthoquinones 1998(45) doi:10.1016/S0040-4039(98)01880-2

Add: Room C316, 150 RenAi Road, Suzhou, P. R. China Tel:0517-86993111;0512-62729923

Copyright: Southeast Pharmaceuticals Co., Ltd. All rights reserved.